vitamin b and c preparations

CLINICAL USE

Vitamin B and C supplementation

DOSE IN NORMAL RENAL FUNCTION

Vitamin B Compound Strong: 1–2 tablets 1 to 3 times daily Pabrinex: Ampoules No 1 and No 2 every 8–12 hours depending on indication Can be given post dialysis for vitamin supplementation

PHARMACOKINETICS

Molecular weight : N/A

%Protein binding : N/A

%Excreted unchanged in urine : N/A

Volume of distribution (L/kg) : N/A

half-life – normal/ESRD (hrs) : N/A

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD : Dialysed. Dose as in normal renal function

HD : Dialysed. Dose as in normal renal function

HDF/high flux : Dialysed. Dose as in normal renal function

CAV/VVHD : Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

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Route

Oral, IV, IM

Rate of Administration

Bolus: Max volume of 10 mL over 10 minutes Infusion: 15–30 minutes

Comments

Dilute in 50–100 mL sodium chloride or glucose 5%

OTHER INFORMATION

NOT PRESCRIBABLE ON FP10 PRESCRIPTION Supplement in

HD : patients due to loss on dialysis and poor diet Available as Nephrovite ® (Kimal) and Dialyvit® (Vitaline) – each tablet contains: Vitamin B1 (thiamine) 1.5 mg Vitamin B2 (riboflavin) 1.7 mg Vitamin B3 (niacinamide) 20 mg Vitamin B6 (pyridoxine) 10 mg Vitamin B12 (cyanocobalamin) 6 mcg Vitamin C 60 mg Biotin 300 mcg Pantothenic acid 10 mg Folic acid 800 mcg Ketovite ®, each tablet contains: Vitamin B1 (thiamine) 1 mg Vitamin B2 (riboflavin) 1 mg Acetomenaphthone 500 mcg Vitamin B6 (pyridoxine) 330 mcg Nicotinamide 3.3 mg Vitamin C 16.6 mg Biotin 170 mcg Pantothenic acid 1.16 mg Alpha tocopheryl acetate 5 mg Inositol 50 mg Folic acid 250 mcg Pabrinex: Vitamin B1 (thiamine) 250 mg Vitamin B2 (riboflavin) 4 mg Vitamin B6 (pyridoxine) 50 mg Vitamin C 500 mg Nicotinamide 160 mg Vitamin B and C preparations .

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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